Vizoovet®Plus  lubricating-Protective-Soothing-Eye Drops for Pets, Long Lasting Relief

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Vizoovet® Plus Nanoparticle Mist

Jett Plasma Veterinary

Vizoovet Plus Precision Drops 10 ml

The Perfect Eye Drop is a Nanoparticle Spray

Vizoovet&reg; was the product of choice for thermal injuries to the eye for the animal victims of the Australian fires. Still used today.

The Perfect Eye Drop

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Nano-Vet&trade; Mist - The First and only Nanoparticle eye drop for pets.

There are 3 categories of nanoparticles. Nano-Vet produces particles of the smallest size category. 1. Nanoparticles&nbsp;have the capacity to deliver ocular drugs to specific target sites and hold promise to revolutionize the therapy of many eye diseases. They can improve penetration, sustained delivery, and controlled release of different drugs for ophthalmic therapeutic applications1,2.

&nbsp;

Applications of nanoparticles in ophthalmology

&nbsp;

Abstract

Nanocarriers, such as nanoparticles, have the capacity to deliver ocular drugs to specific target sites and hold promise to revolutionize the therapy of many eye diseases. Results to date strongly suggest that&nbsp;ocular medicine will benefit enormously from the use of this nanometric scale technology.&nbsp;One of the most important handicaps of the eye as a target organ for drugs is the presence of several barriers that impede direct and systemic drug access to the specific site of action. Superficial barriers include the ocular surface epithelium and the tear film, and internal barriers include the blood-aqueous and blood-retina barriers.&nbsp;Topical application is the preferred route for most drugs, even when the target tissues are at the back part of the eye where intraocular injections are currently the most common route of administration. Direct administration using any of these two routes faces many problems related to drug bioavailability, including side effects and repeated uncomfortable treatments to achieve therapeutic drug levels. In this regard, the advantages of using nanoparticles include improved topical passage of large, poorly water-soluble molecules such as glucocorticoid drugs or cyclosporine for immune-related, vision-threatening diseases.&nbsp;Other large and unstable molecules, such as nucleic acids, delivered using nanoparticles offer promising results for gene transfer therapy in severe retinal diseases. Also, nanoparticle-mediated drug delivery increases the contact time of the administered drug with its target tissue, such as in the case of brimonidine, one of the standard treatments for glaucoma, or corticosteroids used to treat autoimmune uveitis, a severe intraocular inflammatory process. In addition, nanocarriers permit the non-steroidal anti-inflammatory drug indomethacin to reach inner eye structures using the transmucosal route. Finally, nanoparticles allow the possibility of targeted delivery to reach specific types of cancer, such as melanoma, leaving normal cells untouched. This review summarizes experimental results from our group and others since the beginnings of nanocarrier technology to deliver drugs to different locations in the eye. Also, it explores the future possibilities of nanoparticles not only as drug delivery systems but also as aides for diagnostic purposes.

Copyright &copy; 2010 Elsevier Ltd. All rights reserved.

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References

1.&nbsp; ISO ISO/TS 27687:2008 Nanotechnologies - Terminology and definitions for nano objects - nanoparticle, nanofibre and nanoplate.&nbsp;Available at:&nbsp;<a href="http://www.iso.org/iso/iso_catalogue.htm">http://www.iso.org/iso/iso_catalogue.htm</a>

3.&nbsp; ASTM 2456-06 Standard Terminology Relating to Nanotechnology.&nbsp;Available at:&nbsp;<a href="http://www.astm.org/Standard/index.shtml">http://www.astm.org/Standard/index.shtml</a>

4.&nbsp; Scientific Basis for the Definition of the Term &quot;nanomaterial&quot;, ISSN 1831-4783 ISBN 978-92-79-12757-1, doi:10.2772/39703 ND-AS-09-004-EN-N.

4.&nbsp; Burgess, et. al., Particle Size Analysis:&nbsp;AAPS Workshop Report, Cosponsored by the Food and Drug Administration and the United States Pharmaceopeia, The AAPS Journal 2004; 6 (3) Article 20 (<a href="http://www.aaps.org/">http://www.aaps.org</a>).

4.Diebold Y, Calonge M. Applications of nanoparticles in ophthalmology. Prog Retin Eye Res. 2010 Nov;29(6):596-609. doi: 10.1016/j.preteyeres.2010.08.002. Epub 2010 Sep 6. PMID: 20826225.

The Perfect Eye Drop is a Nanoparticle Mist from Petnetwork

Unparalleled Comfort - Effortless Administration -Transformative Experience VIZOOVET®PLUS NANOPARTICLE MIST

Nano-Ophthalmology™ from Petnetwork

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Perfect Drop&trade; relieves all major types of dry eye symptoms by forming a matrix of protection across the entire eye surface&mdash;resulting in better coverage .

Relieves evaporative dry eye symptoms by restoring the eyes&rsquo; lipid layer and replenishing essential moisture to the eye for fast hydration.&nbsp; It works on all 3 types of KCS

Enhanced Penetration:&nbsp;

Nanoparticles can penetrate ocular barriers more effectively than larger particles. This allows them to reach deeper layers of the eye

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