We help you measure your exposure by offering badge-style air samplers that have been specifically validated for the measurement of halogenated anesthetic agents. We analyze these using laboratory methods that are new-and-improved versions of the classic OSHA 103/106 method, but using a modern GC-MS (mass spectrometer) instrument that identifies each substance with very high certainty by measuring mass ions that are specific to each anesthetic gas.  This analysis method allows us to rule out the possibility of an interfering substance (isopropanol, ethyl chloride, methylene chloride), ensuring that your results are correct every time.

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Health Effects of Occupational Exposure to Isoflurane

Acute exposure to isoflurane is well-known among users to cause severe headaches, loss of balance, and fatigue (see brochure from Cal OSHA). Chronic exposure is reportedly linked to deleterious effects on the central nervous system, as well as dose-dependent effects on the cardiopulmonary system as well effects on fertility such as miscarriages and birth defects (see publication from Loc Pokhrel for risk assessment). Consequently, CAL OSHA has set the legal exposure limit to isoflurane to 2 PPM.

How it Works

Wear the badge-style air sampler on the shirt collar when performing a procedure using a halogenated anesthetic. Please note the time the sampler was exposed and return the sampler to the laboratory for analysis.  We provide a written report within 3 working days of receipt of the sampler.

How much is too much?

In the US, the recommended exposure limit for halogenated anesthetics agents is commonly accepted to be 2 PPM (the legal limit in CA).  The original recommendation was made in 1977 by NIOSH, long before the introduction of the halogenated agents used today (isoflurane and sevoflurane), and applies to halothane, chloroform, trichloroethylene, enflurane, methoxyflurane, and fluroxene. NIOSH has announced an effort to determine RELs for these new substances, although the results of these studies have not yet been reported.  Until these limits are established, “the responsible approach to worker health and safety remains to minimize exposure to (these) waste gases to the lowest practical level" (see recommendations from the American College of Veterinary Anesthesia and Analgesia, downloadable doc). Thus, any detectible exposure is potentially harmful (especially if chronic) and needs to be monitored and controlled.  Exposure limits have been established in other countries too. These can be viewed on the German IFA’s GESTIS website.

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